Han salido publicados en la prestigiosa revista The New England Journal of Medicine los primeros resultados tras la inyección de la vacuna anticovid19 del laboratorio Moderna (basada en RNA mensajero).
Brevemente, paso a comentarlos y os dejo enlace al artículo.
- 30.420 participantes.
- 2 dosis de vacunas, separadas por 28 días.
- Eficacia del 94.1%.
- Se contabilizaron 185 infecciones leves en el grupo placebo (no vacuna), frente 11 infecciones leves el grupo vacuna.
- 30 casos de Covid19 severo en el grupo placebo, frente a ninguno en el grupo vacunado.
- Eventos adversos leves más habituales tras la segunda dosis.
- Eficacia similar entre grupos de edad (>65 años baja a la eficacia a 86%).
- Supresión de la transmisión después de la primera dosis, lo cual es un hallazgo muy alentador.
- Es importante examinar a los pacientes antes de la vacunación para detectar posibles respuestas alérgicas y estar al tanto de los primeros signos de una reacción de hipersensibilidad inmediata.
- Hasta la fecha, un número muy reducido de personas que han recibido una vacuna covid19 ha tenido reacciones anafilácticas graves, ninguna mortal.
- Importante efecto “nocebo” de las vacunas (empeoramiento de los síntomas o signos de una enfermedad por la expectativa, consciente o no, de efectos negativos de una medida terapéutica). Así 1 de cada 4 pacientes a los que se les inyecta 0.5 ml de suero fisiológico tienen fatiga o cefalea, más del 10% dolores musculares y articulares…
Cuál es la conclusión que obtengo de estos hallazgos:
Muy eficaz, ningún caso grave. Así pues: #YoMeVacuno.
REFERENCIA
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Baden RL et al. for the COVE Study Group.
N Eng J Med December 30, 2020
DOI: 10.1056/NEJMoa2035389
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